Presurgical opioid effects & postsurgical opioid use

Overview of data collection stages pre- and post-surgery

Opioid analgesics are given to millions of people before and after surgery. Postsurgical opioid treatment carries risk of prolonged opioid use, and it is important to understand postsurgical opioid use across countries with varying prescription practices. Opioid analgesic effects are also the subject of strong beliefs, many of which can be described as myths since they do not reflect the state of the scientific evidence (see e.g. Barnett, 2020, NEJM or this talk by Siri Leknes). In this study at Kongsberg Hospital, we investigate the acute subjective effects of commonly used opioids (morphine, oxycodone, fentanyl) in an ecological setting: the operating table. Importantly, we also gather subjective and prescription data long-term to assess acute and long-term postoperative opioid use in a Norwegian, opioid conservative context. The project is funded by grants to Gernot Ernst, Marie Eikemo and Siri Leknes from the Regional Health Authority. Key team members include Isabell Meier and Eira Jensen.

The Surgery Study team at our kickoff meeting at Kongsberg Hospital in May 2021. From left co-PI Siri Leknes, hospital director Stein-Are Agledal, RA Malin Kvande, co-PIs Marie Eikemo & Gernot Ernst, researcher Eira Jensen, postdoc Isabell Meier and specialist nurse Kaja Eide