Marie Eikemo, Isabell M. Meier, Guro Engvig Løseth, Martin Trøstheim, Nikoline Ørstavik, Eira Nordeng Jensen, Eric Garland, Chantal Berna, Gernot Ernst, and Siri Leknes. “Do Opioid Analgesics Improve Subjective Well-Being? A Prospective Observational Study of Acute Opioid Effects before Surgery.” Preprint PsyArXiv, August 8, 2022. .

Guro E Løseth, Marie Eikemo, Martin Trøstheim, Isabell M. Meier, Herman Bjørnstad, Anna Asratian, Claudia Pazmandi, Vegard Wathne Tangen, Markus Heilig, and Siri Leknes (2022) Stress Recovery with Social Support: A Dyadic Stress and Support Task. Psychoneuroendocrinology 146: 105949. [Preprint PsyArXiv]

Meier, Isabell M., Marie Eikemo, Martin Trøstheim, Kaja Buen, Eira Nordeng Jensen, Siri Gurandsrud Karlsen, Silje Endresen Reme, Chantal Berna, Siri Leknes, and Gernot Ernst. “Factors Associated with Use of Opioid Rescue Medication after Surgery.” Preprint PsyArXiv, September 13, 2022

U Sailer, S Leknes (2022) Meaning makes touch affective. Current Opinion in Behavioral Sciences 44, 101099

Trøstheim M, Eikemo M, Haaker J, Frost JJ, Leknes S (2022). Opioid Antagonism in Humans: A Primer on Optimal Dose and Timing for Central Mu-Opioid Receptor Blockade. Neuropsychopharmacology [preprint BioArXiv]

S Leknes & LY Atlas (2022) Corrigendum to ‘Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology’(Br J Anaesth 2020; 124: e29-e33) British Journal of Anaesthesia

A Parisi, HL Landicho, J Hudak, S Leknes, B Froeliger, EL Garland (2022). Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy. Drug and Alcohol Dependence 233, 109361

C Skoglund, S Leknes, M Heilig (2022). The partial µ-opioid agonist buprenorphine in autism spectrum disorder: a case report. Journal of Medical Case Reports 16 (1), 1-6


Marie Eikemo, Guro Løseth, and Siri Leknes (2021). Do endogenous opioids mediate or fine-tune human
pain relief?
Pain 162(12), 2789-91. Link to preprint.

Isabell M. Meier, Marie Eikemo and Siri Leknes (2021). The role of mu-opioids for reward and threat processing in humans: Bridging the gap from preclinical to clinical opioid drug studies. Current Addiction Reports

S Henningsson, S Leknes, M Asperholm, M Eikemo, L Westberg (2021) A randomized placebo-controlled intranasal oxytocin study on first impressions and reactions to social rejection. Biological Psychology 164, 108164

B Laeng, L Garvija, G Løseth, M Eikemo, G Ernst, S Leknes. (2021) ‘Defrosting’ music chills with naltrexone: The role of endogenous opioids for the intensity of musical pleasure Consciousness and Cognition 90, 103105


Unni Sulutvedt, Daniele Zavagno, Jamie Lubell, Siri Leknes, Sigrid A. de Rodez Benavent, Bruno Laeng. (2020) Brightness perception changes related to pupil size. Vision research. 178:41-47

Hovey D, Martens L, Laeng B, Leknes S, Westberg L. (2020) The effect of intranasal oxytocin on visual processing and salience of human faces. Translational Psychiatry. Sep 19;10(1):318. doi: 10.1038/s41398-020-00991-3.

Martin Trøstheim, Marie Eikemo, Remy Meir, Ingelin Hansen, Elisabeth Paul, Sara Liane Kroll, Eric L Garland & Siri Leknes (2020) Assessment of Anhedonia in Adults With and Without Mental Illness: A Systematic Review and Meta-analysis. JAMA Network Open 3 (8), e2013233-e2013233


Siri Leknes & Lauren Y Atlas (2019). Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology. British Journal of Anaesthesia

Lisa E Hauger, Dominic Sagoe, Anja Vaskinn, Espen A Arnevik, Siri Leknes, Marie L Jørstad & Astrid Bjørnebekk (2019). Anabolic androgenic steroid dependence is associated with impaired emotion recognition. Psychopharmacology 236 (9), 2667-2676

Eric L. Garland, Martin Trøstheim, Marie Eikemo and Siri Leknes (2019). Anhedonia in Chronic Pain and Prescription Opioid Misuse. Psychological Medicine 1- 12

Marie Eikemo, Philipp  P Lobmaier, Mads L Pedersen; Nikolaj Kunøe, Anna-Maria Matziorinis & Siri Leknes*, Monica Sarfi*. (2019) Intact reward responsiveness in long-term opioid maintenance treatment. Neuropsychopharmacology

Guro Løseth, Marie Eikemo and Siri Leknes. (2019) Effects of opioid receptor stimulation and blockade on touch pleasantness: a double-blind randomised trial. Social Cognitive Affective Neuroscience nsz022

Henk van Steenbergen*, Marie Eikemo* and Siri Leknes (2019) The role of the opioid system in decision making and cognitive control. Cognitive Affective and Behavioral Neuroscience


Berna C*, Leknes S*, Ahmad AH, Mhuircheartaigh RN, Goodwin GM, Tracey I (2018) Opioid-Independent and Opioid-Mediated Modes of Pain Modulation. J Neurosci,  38:9047.

Ree A, Mayo LM, Leknes S, Sailer U (2019) Touch targeting C-tactile afferent fibers has a unique physiological pattern: A combined electrodermal and facial electromyography study. Biol Psychol 140:55-63.

Zunhammer, Bingel, Wager, for the Placebo Imaging Consortium (2018). Placebo Effects on the Neurologic Pain Signature: A Meta-analysis of Individual Participant Functional Magnetic Resonance Imaging Data. JAMA Neurology

GE Løseth, M Eikemo, P Isager, J Holmgren, B Laeng, V Vindenes, T Hjørnevik, S Leknes (2018). Morphine reduced perceived anger from neutral and implicit emotional expressions. PNEC , 91:123-31


Marie Eikemo, Guido Biele, Frode Willoch, Lotte Thomsen & Siri Leknes. (2017) Opioid modulation of value-based decision making in healthy humans, Neuropsychopharmacology [Supplementary materials]

Liljencrantz J, Strigo I, ¤Ellingsen D-M, Krämer H, Lundblad L, Nagi S, Leknes S, Olausson H. (2017). Slow brushing reduces heat pain in humans. Eur J Pain


M Eikemo, GE Løseth, T Johnstone, J Gjerstad, F Willoch, S Leknes (2016) Sweet taste pleasantness is modulated by morphine and naltrexone. Psychopharmacology, 1-13

Chelnokova, O., Laeng, B., ¤Løseth, G., ¤Eikemo, M., Willoch, F., & Leknes, S. (2016). The µ-Opioid System Promotes Visual Attention to Faces and Eyes. Social Cognitive and Affective Neuroscience, nsw116.

Brandtzaeg, O. K., Johnsen, E., Roberg-Larsen, H., Seip, K. F., MacLean, E. L., Gesquiere, L. R., Leknes S, Lundanes E, Wilson, S. R. (2016). Proteomics tools reveal startlingly high amounts of oxytocin in plasma and serum. Scientific Reports, 6.

Nilsen, A. S., Blix, I., Leknes, S., Ekeberg, Ø., Skogstad, L., Endestad, T., Østberg BC & Heir, T (2016). Brain activity in response to trauma-specific, negative, and neutral stimuli. A fMRI study of recent road traffic accident survivors. Front Psychol, 7


Ellingsen, D.-M., Leknes, S., & Kringelbach, M. (2015). Hedonic value. In: Handbook of Value: Perspectives from Economics, Neuroscience, Philosophy, Psychology and Sociology, 265-286. Eds: David Sander and Tobias Brosch: Oxford University Press

Johnsen, E, Leknes S, Wilson, SR, Lundanes E (2015) Liquid chromatography-mass spectrometry platform for both small neurotransmitters and neuropeptides in blood, with automatic and robust solid phase extraction. Scientific Reports 5.

Jonassen R, Chelnokova O, Harmer CJ, Leknes S, Landrø NI (2015) A Single dose of Antidepressant Alters Eye-Gaze Patterns across Face stimuli in Healthy Women. Psychopharmacology (Berl) 232:953-958. Epub 7 Sept 2014


Løseth GE, Ellingsen D-M, Leknes S (2014) State-dependent µ-opioid Modulation of Social Motivation – a model. Front Behav Neurosci 8.

Bastian B, Jetten J, Hornsey M, Leknes S (2014) The positive consequences of pain: A biopsychosocial approach. Personality and Social Psychology Review 18:256-279.

Chelnokova O, Laeng B, Eikemo M, Riegels J, Løseth G, Maurud H, Willoch F, Leknes S (2014) Rewards of Beauty: The Opioid System Mediates Social Motivation in Humans. Mol Psychiatry 19:746-747. [Supplementary materials]

Ellingsen D-M, Wessberg J, Chelnokova O, Olausson H, Laeng B, Leknes S (2014) In touch with your emotions: Oxytocin and touch change social impressions while others’ facial expressions can alter touch. Psychoneuroendocrinology 39:11-20.

Leknes S, Bastian B (2014) The benefits of pain. The Review in Philosophy and Psychology 5:57-70.

Leknes S, Bastian B (2014) How does pain affect eating and food pleasure? Pain 155:652-653. How does pain affect eating and food pleasure? Pain 155:652-653.


Ellingsen D-M, Wessberg J, Eikemo M, Liljencrantz J, Endestad T, Olausson H, Leknes S (2013) Placebo improves pleasure and pain through opposite modulation of sensory processing. Proc Natl Acad Sci U S A 110:17993–17998.

Ellingsen D-M, Leknes S (2013) Placebo gav lindrad smärta, men också ökad njutning. Lakartidningen 110:CLEF.

Leknes S, Berna C, Lee MC, Snyder GD, Biele G, Tracey I (2013) The importance of context: When relative relief renders pain pleasant. Pain 154:402-410.

Leknes S, Berna C, Lee MC, Snyder GD, Biele G, Tracey I (2013) Response to the commentary “Multiple potential mechanisms for context effects on pain” Pain 154:1485-1486.

Leknes S, Wessberg J, Ellingsen D-M, Chelnokova O, Olausson H, Laeng B (2013) Oxytocin enhances pupil dilation and sensitivity to ‘hidden’ emotional expressions. Soc Cogn Affect Neurosci 8:741-749.

Løseth GE, Ellingsen D-M, Leknes S (2013) Touch and Pain. In: Noba textbook series: Psychology (Biswas-Diener, R. and Diener, E., eds) Champaign, IL: DEF Publishers.


Wanigasekera V, Lee MC, Rogers R, Kong Y, Leknes S, Andersson J, Tracey I (2012) Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects. PNAS 109:17705-17710.


Leknes S, Lee M, Berna C, Andersson J, Tracey I (2011) Relief as a Reward: Hedonic and Neural Responses to Safety from Pain. PLoS ONE 6:e17870.

Leknes S (2011) The pain modulatory cocktail. Scand J Pain 2:105-107How does pain affect eating and food pleasure? Pain 155:652-653.


Berna C, Leknes S, Holmes EA, Edwards RR, Goodwin GM, Tracey I (2010) Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biol Psychiatry 67:1083-1090. [Supplementary materials]

Leknes S, Tracey I (2010) Pain and Pleasure: Masters of Mankind. In: Pleasures of the brain: the neural basis of sensory rewards (Kringelbach, M. L. and Berridge, K. C., eds), pp 320-335 New York: Oxford University Press.


Leknes S, Tracey I (2008) A common neurobiology for pain and pleasure. Nat Rev Neurosci 9:314-320.

Leknes S, Brooks JCW, Wiech K, Tracey I (2008) Pain relief as an opponent process: a psychophysical investigation. Eur J Neurosci 28:794-801.


Leknes SG, Bantick S, Willis CM, Wilkinson JD, Wise RG, Tracey I (2007) Itch and Motivation to Scratch: An Investigation of the Central and Peripheral Correlates of Allergen- and Histamine-Induced Itch in Humans. J Neurophysiol 97:415-422.

Leknes S, Tracey I (2007) Hippocampus and Entorhinal Complex, Functional Imaging. In: Encyclopedia of Pain, pp 8-8.

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